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Type : Research & Development – CRO.
Domains : Biotransformations of Xenobiotics and studies of residues (pharmaceutical compounds, pesticides, chemicals) in animal, soil, plant and human.
Activities : Pharmacokinetics, toxicokinetics, metabolism, distribution, excretion, residues.
Methods : HPLC, LC-MS-MS, RIA, EIA, cryosection, image analysis.
Tracers : Use of radiolabelled isotopes and stable isotopes.
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Hypertension
Chronobiology
Fertility
Neurotransmitters
Diabetes
Inflammation |
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Extraction disk plate 96-wells.
LC/MS-MS
LC/ED, UV, Fluo, RA
Parent compound and metabolites.
Structural identification MS NMR.
Protein binding.
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Automated blood sampling.
Hands off dosing via IV, gastric, duodenum.
Mass balance U/F/CO2
Rat, dog, human. |
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CYP involvement
CYP induction
CYP inhibition
Drug-drug interactions
In vitro => in vivo
Rat, Dog, Monkey
=> Human |
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Quantitative whole body tissue distribution : QRLG
Blood-brain barrier transfer
Transplacental passage
Skin permeation
Melanin affinity |
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