BIOTEC CENTRE PICRA Member - ADME, DMPK, CULEX & CRO
Image analysis : monkey brain Automated blood center CRO Bioanalysis using Mass Spectrometry Elderly subjects are also studied
Biotec Centre : PICRA Member' company
 


Type : Research & Development – CRO.

Domains : Biotransformations of Xenobiotics and studies of residues (pharmaceutical compounds, pesticides, chemicals) in animal, soil, plant and human.
Activities : Pharmacokinetics, toxicokinetics, metabolism, distribution, excretion, residues.
Methods : HPLC, LC-MS-MS, RIA, EIA, cryosection, image analysis.
Tracers : Use of radiolabelled isotopes and stable isotopes.

Biotec : biomarkersHypertension
Chronobiology
Fertility
Neurotransmitters
Diabetes
Inflammation

Biotec : bioanalysisExtraction disk plate 96-wells.
LC/MS-MS
LC/ED, UV, Fluo, RA
Parent compound and metabolites.
Structural identification MS NMR


Structural identification MS NMR.
Protein binding.

Various phases

Biotec : ADME and Culex

Automated blood sampling.
Hands off dosing via IV, gastric, duodenum.
Mass balance U/F/CO2
Rat, dog, human.

Biotec : metabolismCYP involvement
CYP induction
CYP inhibition
Drug-drug interactions
In vitro => in vivo
Rat, Dog, Monkey
=> Human
Biotec : image analysis Quantitative whole body tissue distribution : QRLG
Blood-brain barrier transfer
Transplacental passage
Skin permeation
Melanin affinity
 
BIOTEC CENTRE - 10, avenue Claude Guillemin - 45071 Orléans Cedex 2 Biotec centre laboratory France - Phone : +(33) 2 38 76 20 60 - Fax : +(33) 2 38 76 20 59 - Contact E-mail
BIOTEC CENTRE - Siret 351 376 025 00018 - TVA : FR 84 351 376 025 00018 - Mentions légales
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